well, the v-block clamp once tightened, should prevent the barrel from moving around in the receiver. I would periodically check on it to see if its loose, and make a set of witness marks on the barrel receiver connection to check for shifting.
The only time Ive seen a heavy barreled 10/22's barrel shift around was when it was used for hunting and was kicked around a bit. Using a steel v-block should help prevent this.
http://www.brownells.com/.aspx/sid=17030/sku/10_22_V_Block
If you decide to bed it, that will help too, but Id rather have a match 10/22 free floated, so if you can help it, dont bed unless its for accuracy purposes.
You better post up some pics once youre done with them!